α-Catulin, a Rho signalling component, can regulate NF-κB through binding to IKK-β, and confers resistance to apoptosis

C. Wiesner, G. Winsauer, U. Resch, M. Hoeth, Johannes Schmid, J. Van Hengel, F. van Roy, B.R. Binder, R. De Martin

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

Abstract

Rho GTPases regulate diverse cellular functions including adhesion, cytokinesis and motility, as well as the activity of the transcription factors NF-κB, serum response factor and C/EBP. α-Catulin, an α-catenin-related protein that shares structural similarities with cytoskeletal linker proteins, facilitates Rho signalling by serving as a scaffold for the Rho-specific guanine nucleotide exchange factor Lbc. We report here that α-catulin also interacts with a key component of the NF-κB signalling pathway, namely the IκB kinase (IKK)-β. In co-immunoprecipitations, α-catulin can bind IKK-β and Lbc. Ectopic expression of α-catulin augmented NF-κB activity, promoted cell migration and increased resistance to apoptosis, whereas knockdown experiments showed the opposite effects. Together, these features suggest that α-catulin has tumorigenic potential. © 2008 Nature Publishing Group All rights reserved.
OriginalspracheEnglisch
Seiten (von - bis)2159-2169
Seitenumfang11
FachzeitschriftOncogene
Jahrgang27
Ausgabenummer15
DOIs
PublikationsstatusVeröffentlicht - 2008
Extern publiziertJa

IMC Forschungsschwerpunkte

  • Medical biotechnology

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

  • 304005 Medizinische Biotechnologie

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