Abstract
Rho GTPases regulate diverse cellular functions including adhesion, cytokinesis and motility, as well as the activity of the transcription factors NF-κB, serum response factor and C/EBP. α-Catulin, an α-catenin-related protein that shares structural similarities with cytoskeletal linker proteins, facilitates Rho signalling by serving as a scaffold for the Rho-specific guanine nucleotide exchange factor Lbc. We report here that α-catulin also interacts with a key component of the NF-κB signalling pathway, namely the IκB kinase (IKK)-β. In co-immunoprecipitations, α-catulin can bind IKK-β and Lbc. Ectopic expression of α-catulin augmented NF-κB activity, promoted cell migration and increased resistance to apoptosis, whereas knockdown experiments showed the opposite effects. Together, these features suggest that α-catulin has tumorigenic potential. © 2008 Nature Publishing Group All rights reserved.
Originalsprache | Englisch |
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Seiten (von - bis) | 2159-2169 |
Seitenumfang | 11 |
Fachzeitschrift | Oncogene |
Jahrgang | 27 |
Ausgabenummer | 15 |
DOIs | |
Publikationsstatus | Veröffentlicht - 2008 |
Extern publiziert | Ja |
IMC Forschungsschwerpunkte
- Medical biotechnology
ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige
- 304005 Medizinische Biotechnologie