@article{7bc4cebb78e84a61a6b1610368bead74,
title = "A β-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: Synthesis and biological evaluation: Angewandte Chemie - International Edition",
abstract = "New drug design possibilities are suggested by the results of a biological evaluation of the indole derivative 1 of pancratistatin, a known anticancer agent, in a panel of cancer cell lines. Enzymatic dihydroxylation was one of the key steps in the short, enantioselective synthesis of 1.",
keywords = "Antitumor agents, Asymmetric synthesis, Natural products, Pancratistatin, Synthetic methods, Amaryllidaceae Alkaloids, Antineoplastic Agents, Phytogenic, Carbolines, Hydrogen Bonding, Isoquinolines, Molecular Mimicry, Molecular Structure, Plants, Medicinal, Stereoisomerism, Cells, Synthesis (chemical), Tumors, 7 deoxypancratistatin, beta carbolin 1 one, beta carboline derivative, hydroxyl group, lycoricidine, narciclasine, natural product, pancratistatin, phenanthridine derivative, unclassified drug, amaryllidaceae, antineoplastic activity, article, asymmetric synthesis, electricity, geometry, molecular model, nuclear magnetic resonance imaging, pharmacophore, plant, RNA transcription, Enzymatic dihydroxylation, Indole derivatives, Drug therapy",
author = "U. Rinner and T. Hudlicky and H. Gordon and G.R. Pettit",
note = "Export Date: 13 June 2023; Cited By: 78; Correspondence Address: T. Hudlicky; Department of Chemistry, Brock University, St. Catharines, Ont. L2S 3A1, 500 Glenridge Avenue, Canada; email:
[email protected]; CODEN: ACIEA",
year = "2004",
month = oct,
day = "5",
doi = "10.1002/anie.200460218",
language = "English",
volume = "43",
pages = "5342--5346",
journal = "Angew. Chem. Int. Ed.",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "40",
}
