Design and synthesis of benzothiazole schiff bases of potential antitumor activity

T. Al-Harthy; R. Abdel-Jalil; W.M. Zoghaib; M. Pflüger; E. Hofmann; H. Hundsberger

doi:10.3987/COM-16-13471

Design and synthesis of benzothiazole schiff bases of potential antitumor activity

T. Al-Harthy, R. Abdel-Jalil, W.M. Zoghaib, M. Pflüger, E. Hofmann, H. Hundsberger

Institut Biotechnologie

Sultan Qaboos University

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

Abstract

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

Originalsprache	Englisch
Seiten (von - bis)	1282-1292
Seitenumfang	11
Fachzeitschrift	Heterocycles
Jahrgang	92
Ausgabenummer	7
DOIs	https://doi.org/10.3987/COM-16-13471
Publikationsstatus	Veröffentlicht - 25 Mai 2016

IMC Forschungsschwerpunkte

Medical biotechnology

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

304005 Medizinische Biotechnologie

UN SDGs

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abstract = "In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.",

author = "T. Al-Harthy and R. Abdel-Jalil and W.M. Zoghaib and M. Pfl{\"u}ger and E. Hofmann and H. Hundsberger",

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doi = "10.3987/COM-16-13471",

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AU - Al-Harthy, T.

AU - Abdel-Jalil, R.

AU - Zoghaib, W.M.

AU - Pflüger, M.

AU - Hofmann, E.

AU - Hundsberger, H.

PY - 2016/5/25

Y1 - 2016/5/25

N2 - In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

AB - In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

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U2 - 10.3987/COM-16-13471

DO - 10.3987/COM-16-13471

M3 - Article

SN - 0385-5414

VL - 92

SP - 1282

EP - 1292

JO - Heterocycles

JF - Heterocycles

IS - 7

ER -

Design and synthesis of benzothiazole schiff bases of potential antitumor activity

Abstract

IMC Forschungsschwerpunkte

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

UN SDGs

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