Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

C. Wiesner, J. Kopecky, M. Pflueger, H. Hundsberger, B. Entler, C. Kleber, J. Atzler, P. Hrouzek, D. Stys, A. Lukesova, W. Schuett, R. Lucas

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

Abstract

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.
OriginalspracheEnglisch
Seiten (von - bis)254-260
Seitenumfang7
FachzeitschriftDrug Metabolism Letters
Jahrgang1
Ausgabenummer4
DOIs
PublikationsstatusVeröffentlicht - Dez. 2007

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