GRC5 and NMD3 function in translational control of gene expression and interact genetically

T. Karl; K. Önder; R. Kodzius; A. Pichová; H. Wimmer; A. Thür; H. Hundsberger; M. Löffler; T. Klade; A. Beyer; M. Breitenbach; L. Koller

doi:10.1007/s002940050416

GRC5 and NMD3 function in translational control of gene expression and interact genetically

T. Karl, K. Önder, R. Kodzius, A. Pichová, H. Wimmer, A. Thür, H. Hundsberger, M. Löffler, T. Klade, A. Beyer, M. Breitenbach, L. Koller

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

Abstract

The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1(t)s allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p.

Originalsprache	Englisch
Seiten (von - bis)	419-429
Seitenumfang	11
Fachzeitschrift	Current Genetics
Jahrgang	34
Ausgabenummer	6
DOIs	https://doi.org/10.1007/s002940050416
Publikationsstatus	Veröffentlicht - 1999
Extern publiziert	Ja

IMC Forschungsschwerpunkte

Medical biotechnology

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

304005 Medizinische Biotechnologie

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

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10.1007/s002940050416

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title = "GRC5 and NMD3 function in translational control of gene expression and interact genetically",

abstract = "The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1(t)s allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p.",

keywords = "messenger RNA, ribosome protein, article, controlled study, gene expression, gene mutation, genetic analysis, growth regulation, human, multigene family, nephroblastoma, nonhuman, nonsense mutation, phenotype, point mutation, priority journal, protein interaction, revertant, saccharomyces cerevisiae, translation regulation, Alleles, Amino Acid Sequence, Animals, Base Sequence, DNA Primers, Gene Expression Regulation, Genes, Fungal, Humans, Molecular Sequence Data, Mutation, Phenotype, Protein Biosynthesis, Ribosomal Proteins, Saccharomyces cerevisiae, Sequence Homology, Amino Acid, Wilms Tumor, Eukaryota",

author = "T. Karl and K. {\"O}nder and R. Kodzius and A. Pichov{\'a} and H. Wimmer and A. Th{\"u}r and H. Hundsberger and M. L{\"o}ffler and T. Klade and A. Beyer and M. Breitenbach and L. Koller",

note = "cited By 45",

year = "1999",

doi = "10.1007/s002940050416",

language = "English",

volume = "34",

pages = "419--429",

journal = "Current Genetics",

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TY - JOUR

T1 - GRC5 and NMD3 function in translational control of gene expression and interact genetically

AU - Karl, T.

AU - Önder, K.

AU - Kodzius, R.

AU - Pichová, A.

AU - Wimmer, H.

AU - Thür, A.

AU - Hundsberger, H.

AU - Löffler, M.

AU - Klade, T.

AU - Beyer, A.

AU - Breitenbach, M.

AU - Koller, L.

N1 - cited By 45

PY - 1999

Y1 - 1999

N2 - The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1(t)s allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p.

AB - The yeast gene, GRC5 (growth control), is a member of the highly conserved QM gene family, the human member of which has been associated with the suppression of Wilms' tumor. GRC5 encodes ribosomal protein L10, which is thought to play a regulatory role in the translational control of gene expression. A revertant screen identified four spontaneous revertants of the mutant grc5-1(t)s allele. Genetic and phenotypic analysis showed that these represent one gene, NMD3, and that the interaction of NMD3 and GRC5 is gene-specific. NMD3 was previously identified as a component of the nonsense-mediated mRNA decay pathway. The point mutations within NMD3 reported here may define a domain important for the functional interaction of Grc5p and Nmd3p.

KW - messenger RNA

KW - ribosome protein

KW - article

KW - controlled study

KW - gene expression

KW - gene mutation

KW - genetic analysis

KW - growth regulation

KW - human

KW - multigene family

KW - nephroblastoma

KW - nonhuman

KW - nonsense mutation

KW - phenotype

KW - point mutation

KW - priority journal

KW - protein interaction

KW - revertant

KW - saccharomyces cerevisiae

KW - translation regulation

KW - Alleles

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - DNA Primers

KW - Gene Expression Regulation

KW - Genes

KW - Fungal

KW - Humans

KW - Molecular Sequence Data

KW - Mutation

KW - Phenotype

KW - Protein Biosynthesis

KW - Ribosomal Proteins

KW - Saccharomyces cerevisiae

KW - Sequence Homology

KW - Amino Acid

KW - Wilms Tumor

KW - Eukaryota

U2 - 10.1007/s002940050416

DO - 10.1007/s002940050416

M3 - Article

SN - 0172-8083

VL - 34

SP - 419

EP - 429

JO - Current Genetics

JF - Current Genetics

IS - 6

ER -

GRC5 and NMD3 function in translational control of gene expression and interact genetically

Abstract

IMC Forschungsschwerpunkte

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

UN SDGs

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