High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer

Piotr Tymoszuk, Pornpimol Charoentong, Hubert Hackl, Rita Spilka, Elisabeth Müller-Holzner, Zlatko Trajanoski, Peter Obrist, Françoise Revillion, Jean-Philippe Peyrat, Heidi Fiegl, Wolfgang Doppler

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

Abstract

STAT1 has been attributed a function as tumor suppressor. However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA expression levels of STAT1 and STAT1 target genes belonging to the interferon-related signature for a poor response to therapy. To clarify this issue we have determined STAT1 expression levels and activation by different methods, and investigated their association with tumor infiltration by immune cells. Additionally, we evaluated the interrelationship of these parameters and their significance for predicting disease outcome.
OriginalspracheEnglisch
Aufsatznummer257
Seiten (von - bis)257
FachzeitschriftBMC Cancer
Jahrgang14
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - 12 Apr. 2014
Extern publiziertJa

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