Inclusion complexation with cyclodextrins

C. T. Klein, H. Viernstein, P. Wolschann

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

Abstract

Inclusion of guest molecules into the hydrophobic cavity of various cyclodextrins changes the properties of these guest molecules, which can be used for a broad variety of applications. Prediction models obtained from QSAR studies lead to a better understanding of the inclusion mechanism. A special feature of such complexation is the enthalpy-entropy compensation and pronounced solubility enhancements, which are used for better bioavailability of drugs and, in the case of biocides for a reduction of the biologically active compounds by equal activity.

OriginalspracheEnglisch
Seiten (von - bis)287-292
Seitenumfang6
FachzeitschriftMinerva Biotecnologica
Jahrgang12
Ausgabenummer4
PublikationsstatusVeröffentlicht - 2000
Extern publiziertJa

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