@article{7dee2f97c27842068f3cd9499ad2ec9e,
title = "Models of epithelial-mesenchymal transition",
abstract = "The spread of cells from the primary neoplasm to distant organs is the most fearsome aspect of cancer. This process of cancer progression denoted as metastasis has exceptional clinical relevance and represents the major reason for the death of cancer patients. Owing to the lack of suitable models, the complex molecular mechanisms underlying metastasis are still poorly understood. Here we focus on epithelial to mesenchymal transition, a developmental event central to cancer progression, and discuss its significance as metastasis model. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",
keywords = "epidermal growth factor, fibroblast growth factor 1, integrin linked kinase, matrix metalloproteinase, mitogen activated protein kinase, phosphatidylinositol 3 kinase, protein tyrosine kinase, Raf protein, Ras protein, Rho guanine nucleotide binding protein, somatomedin C, transcription factor AP 1, transforming growth factor beta, uvomorulin, Wnt protein, article, cancer cell, cancer growth, cancer invasion, cancer model, cancer patient, cell culture, cell differentiation, cell spreading, death, downstream processing, epithelium cell, gene overexpression, human, in vitro study, in vivo study, mesenchyme cell, metastasis, molecular mechanics, nonhuman, nucleotide sequence, protein expression, protein function, signal transduction, transcription regulation, transitional cell carcinoma, upregulation",
author = "A. Eger and W. Mikulits",
note = "cited By 31",
year = "2005",
doi = "10.1016/j.ddmod.2005.04.001",
language = "English",
volume = "2",
pages = "57--63",
journal = "Drug Discovery Today: Disease Models",
publisher = "Elsevier Ltd",
number = "1",
}
