Morphine alkaloids: History, biology, and synthesis

C. Wicks; T. Hudlicky; U. Rinner

doi:10.1016/bs.alkal.2021.04.001

Morphine alkaloids: History, biology, and synthesis

C. Wicks, T. Hudlicky, U. Rinner

Institut Applied Chemistry

Brock University

Publikation: Beitrag in Buch/Bericht/Konferenzband › Kapitel › Begutachtung

Abstract

This chapter provides a short overview of the history of morphine since it's isolation by Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal syntheses of morphine and codeine published after 1996 are discussed in detail. The last section of this chapter provides a detailed overview of medicinally relevant derivatives of the title alkaloid.

Originalsprache	Englisch
Titel	Alkaloids
Untertitel	Chemistry and Biology
Redakteure/-innen	Hans-Joachim Knölker
Herausgeber (Verlag)	Academic Press Inc.
Seiten	145-342
Seitenumfang	198
Band	86
ISBN (Print)	9780128246184
DOIs	https://doi.org/10.1016/bs.alkal.2021.04.001
Publikationsstatus	Veröffentlicht - 21 Sep. 2021

Publikationsreihe

Name	Alkaloids: Chemistry and Biology
Band	86
ISSN (Print)	1099-4831

Forschungsfelder

Alkaloide
Gesamtsynthese
Natürliche Produkte
Biologische Aktivität

IMC Forschungsschwerpunkte

Materials science

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

301305 Medizinische Chemie
104015 Organische Chemie

UN SDGs

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10.1016/bs.alkal.2021.04.001

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title = "Morphine alkaloids: History, biology, and synthesis",

abstract = "This chapter provides a short overview of the history of morphine since it's isolation by Sert{\"u}rner in 1805. The biosynthesis of the title alkaloid as well as all total and formal syntheses of morphine and codeine published after 1996 are discussed in detail. The last section of this chapter provides a detailed overview of medicinally relevant derivatives of the title alkaloid.",

keywords = "Alkaloids, Analgesia, Codeine, Medicinal derivatives, Morphine, Opioids, Opium, Total synthesis, Biology, alkaloid, codeine, morphine, biology",

author = "C. Wicks and T. Hudlicky and U. Rinner",

note = "Funding Information: The Hudlicky group members are grateful to the following agencies for financial support of work related to opiate synthesis: Mallinckrodt (1992–1994); National Science Foundation (1994–2002); ACS Petroleum Research Fund (2002–2005); Natural Sciences and Engineering Research Council of Canada (2003 to date); Canada Research Chairs Program 2003 to date); Canada Foundation for Innovation; TDC Research, Inc.; TDC Research Foundation; Ontario Partnership for Innovation and Commercialization; Advanced Biomanufacturing Centre (Brock University, 2013 to date); Noramco, Inc. (2006–2016). The authors thank all the students and postdocs who worked on morphinan-related projects since 1992; their names are listed in the relevant citations. UR is grateful to the IMC University of Applied Sciences Krems for financial support. Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = sep,

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doi = "10.1016/bs.alkal.2021.04.001",

language = "English",

isbn = "9780128246184",

volume = "86",

series = "Alkaloids: Chemistry and Biology",

publisher = "Academic Press Inc.",

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editor = "Hans-Joachim Kn{\"o}lker",

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TY - CHAP

T1 - Morphine alkaloids: History, biology, and synthesis

AU - Wicks, C.

AU - Hudlicky, T.

AU - Rinner, U.

N1 - Funding Information: The Hudlicky group members are grateful to the following agencies for financial support of work related to opiate synthesis: Mallinckrodt (1992–1994); National Science Foundation (1994–2002); ACS Petroleum Research Fund (2002–2005); Natural Sciences and Engineering Research Council of Canada (2003 to date); Canada Research Chairs Program 2003 to date); Canada Foundation for Innovation; TDC Research, Inc.; TDC Research Foundation; Ontario Partnership for Innovation and Commercialization; Advanced Biomanufacturing Centre (Brock University, 2013 to date); Noramco, Inc. (2006–2016). The authors thank all the students and postdocs who worked on morphinan-related projects since 1992; their names are listed in the relevant citations. UR is grateful to the IMC University of Applied Sciences Krems for financial support. Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/9/21

Y1 - 2021/9/21

N2 - This chapter provides a short overview of the history of morphine since it's isolation by Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal syntheses of morphine and codeine published after 1996 are discussed in detail. The last section of this chapter provides a detailed overview of medicinally relevant derivatives of the title alkaloid.

AB - This chapter provides a short overview of the history of morphine since it's isolation by Sertürner in 1805. The biosynthesis of the title alkaloid as well as all total and formal syntheses of morphine and codeine published after 1996 are discussed in detail. The last section of this chapter provides a detailed overview of medicinally relevant derivatives of the title alkaloid.

KW - Alkaloids

KW - Analgesia

KW - Codeine

KW - Medicinal derivatives

KW - Morphine

KW - Opioids

KW - Opium

KW - Total synthesis

KW - Biology

KW - alkaloid

KW - codeine

KW - morphine

KW - biology

UR - http://www.scopus.com/inward/record.url?scp=85115417566&partnerID=8YFLogxK

U2 - 10.1016/bs.alkal.2021.04.001

DO - 10.1016/bs.alkal.2021.04.001

M3 - Chapter

SN - 9780128246184

VL - 86

T3 - Alkaloids: Chemistry and Biology

SP - 145

EP - 342

BT - Alkaloids

A2 - Knölker, Hans-Joachim

PB - Academic Press Inc.

ER -

Morphine alkaloids: History, biology, and synthesis

Abstract

Publikationsreihe

Forschungsfelder

IMC Forschungsschwerpunkte

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

UN SDGs

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren