Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore

Alexander Dudziak, Lena Engelhard, Cole Bourque, Björn Udo Klink, Pascaline Rombaut, Nikolay Kornakov, Karolin Jänen, Franz Herzog, Christos Gatsogiannis, Stefan Westermann

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

Abstract

Kinetochores form the link between chromosomes and microtubules of the mitotic spindle. The heterodecameric Dam1 complex (Dam1c) is a major component of the Saccharomyces cerevisiae outer kinetochore, assembling into 3 MDa-sized microtubule-embracing rings, but how ring assembly is specifically initiated in vivo remains to be understood. Here, we describe a molecular pathway that provides local control of ring assembly during the establishment of sister kinetochore bi-orientation. We show that Dam1c and the general microtubule plus end-associated protein (+TIP) Bim1/EB1 form a stable complex depending on a conserved motif in the Duo1 subunit of Dam1c. EM analyses reveal that Bim1 crosslinks protrusion domains of adjacent Dam1c heterodecamers and promotes the formation of oligomers with defined curvature. Disruption of the Dam1c-Bim1 interaction impairs kinetochore localization of Dam1c in metaphase and delays mitosis. Phosphorylation promotes Dam1c-Bim1 binding by relieving an intramolecular inhibition of the Dam1 C-terminus. In addition, Bim1 recruits Bik1/CLIP-170 to Dam1c and induces formation of full rings even in the absence of microtubules. Our data help to explain how new kinetochore end-on attachments are formed during the process of attachment error correction.

OriginalspracheEnglisch
Aufsatznummere108004
Seiten (von - bis)e108004
FachzeitschriftEMBO Journal
Jahrgang40
Ausgabenummer18
DOIs
PublikationsstatusVeröffentlicht - 15 Sep. 2021
Extern publiziertJa

Forschungsfelder

  • Cell Division
  • Chemical Crosslinking
  • Mass spectrometry

IMC Forschungsschwerpunkte

  • Medical biotechnology

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

  • 106037 Proteomik
  • 106041 Strukturbiologie
  • 106044 Systembiologie

Fingerprint

Untersuchen Sie die Forschungsthemen von „Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren