Abstract
Kinetochores form the link between chromosomes and microtubules of the mitotic spindle. The heterodecameric Dam1 complex (Dam1c) is a major component of the Saccharomyces cerevisiae outer kinetochore, assembling into 3 MDa-sized microtubule-embracing rings, but how ring assembly is specifically initiated in vivo remains to be understood. Here, we describe a molecular pathway that provides local control of ring assembly during the establishment of sister kinetochore bi-orientation. We show that Dam1c and the general microtubule plus end-associated protein (+TIP) Bim1/EB1 form a stable complex depending on a conserved motif in the Duo1 subunit of Dam1c. EM analyses reveal that Bim1 crosslinks protrusion domains of adjacent Dam1c heterodecamers and promotes the formation of oligomers with defined curvature. Disruption of the Dam1c-Bim1 interaction impairs kinetochore localization of Dam1c in metaphase and delays mitosis. Phosphorylation promotes Dam1c-Bim1 binding by relieving an intramolecular inhibition of the Dam1 C-terminus. In addition, Bim1 recruits Bik1/CLIP-170 to Dam1c and induces formation of full rings even in the absence of microtubules. Our data help to explain how new kinetochore end-on attachments are formed during the process of attachment error correction.
Originalsprache | Englisch |
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Aufsatznummer | e108004 |
Seiten (von - bis) | e108004 |
Fachzeitschrift | EMBO Journal |
Jahrgang | 40 |
Ausgabenummer | 18 |
DOIs | |
Publikationsstatus | Veröffentlicht - 15 Sep. 2021 |
Extern publiziert | Ja |
Forschungsfelder
- Cell Division
- Chemical Crosslinking
- Mass spectrometry
IMC Forschungsschwerpunkte
- Medical biotechnology
ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige
- 106037 Proteomik
- 106041 Strukturbiologie
- 106044 Systembiologie