Sources for structure formation and switches in metabolic pathways

Christian Th Klein, Bernd Mayer

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

Abstract

Zonation of function, i.e. localization of metabolic activity in certain regions of histologically uniform tissues, is an often observed phenomenon. Moreover, experiments show that such metabolic patterns are highly dynamical. Since in the pathways of intermediary metabolism no autocatalytic reactions are observed, different types of metabolic regulation are sources of the non-linearities necessary for structure formation. Two models of biochemical reactions frequently encountered in metabolic pathways, namely a bisubstrate kinetics model with substrate inhibition, and an allosteric model with product regulation, are presented. It is shown, that they are well-suited to reproduce the dynamical behavior suggested by experimental findings, like their capability to act as switches, or their ability for spatio-temporal pattern formation in mature tissues. Copyright (C) 1999 Elsevier Science Ireland Ltd.

OriginalspracheEnglisch
Seiten (von - bis)41-52
Seitenumfang12
FachzeitschriftBioSystems
Jahrgang51
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - Juli 1999
Extern publiziertJa

Fingerprint

Untersuchen Sie die Forschungsthemen von „Sources for structure formation and switches in metabolic pathways“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren