Synthesis of amaryllidaceae constituents - An update

U. Rinner; T. Hudlicky

doi:10.1055/s-2005-862382

Synthesis of amaryllidaceae constituents - An update

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

Abstract

Recent progress in the synthesis of major constituents of the Amaryllidaceae family is reviewed. Total syntheses of pancratistatin, narciclasine, and their 7-deoxy- derivatives, 7-deoxypancratistatin and lycoricidine, respectively, are covered in detail. Also included are preparations of truncated derivatives and unnatural mimics of pancratistatin. The literature coverage begins with the publication of the last major review in 1996 and is complete through the fall of 2004. © Georg Thieme Verlag Stuttgart.

Originalsprache	Englisch
Seiten (von - bis)	365-387
Seitenumfang	23
Fachzeitschrift	Synlett
Ausgabenummer	3
DOIs	https://doi.org/10.1055/s-2005-862382
Publikationsstatus	Veröffentlicht - 16 Feb. 2005
Extern publiziert	Ja

Forschungsfelder

Alkaloide
Amaryllidaceae-Alkaloide
Gesamtsynthese
Stereoselektive Synthese
Biologische Aktivität

IMC Forschungsschwerpunkte

Materials science

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

104015 Organische Chemie
104013 Naturstoffchemie
301305 Medizinische Chemie

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

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10.1055/s-2005-862382

https://www.scopus.com/inward/record.uri?eid=2-s2.0-14644422595&doi=10.1055%2fs-2005-862382&partnerID=40&md5=ba8a7d6358b44c5510efe927f6677368

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@article{b02ac0f0f6b94d4d9f002defd724682a,

title = "Synthesis of amaryllidaceae constituents - An update",

abstract = "Recent progress in the synthesis of major constituents of the Amaryllidaceae family is reviewed. Total syntheses of pancratistatin, narciclasine, and their 7-deoxy- derivatives, 7-deoxypancratistatin and lycoricidine, respectively, are covered in detail. Also included are preparations of truncated derivatives and unnatural mimics of pancratistatin. The literature coverage begins with the publication of the last major review in 1996 and is complete through the fall of 2004. {\textcopyright} Georg Thieme Verlag Stuttgart.",

keywords = "Amaryllidaceae constituents (alkaloids), Total synthesis, Unnatural and truncated derivatives, 7 deoxypancratistatin, antineoplastic agent, lycoricidine, narciclasine, natural product, pancratistatin, phenanthridone, toluenesulfonamide derivative, unclassified drug, acetylation, amaryllidaceae, animal cell, antineoplastic activity, cyclization, cycloaddition, deprotection reaction, Diels Alder reaction, drug screening, drug synthesis, epimerization, esterification, human, human cell, metallation, Mitsunobu reaction, mouse, nonhuman, oxidation, plant, reaction analysis, review, ring closing metathesis, saponification, structure activity relation, Suzuki reaction",

author = "U. Rinner and T. Hudlicky",

note = "Export Date: 13 June 2023; Cited By: 119; Correspondence Address: T. Hudlicky; Department of Chemistry, Brock University, St. Catharines, Ont. L2S 3A1, 500 Glenridge Avenue, Canada; email: [email protected]; CODEN: SYNLE",

year = "2005",

month = feb,

day = "16",

doi = "10.1055/s-2005-862382",

language = "English",

pages = "365--387",

journal = "Synlett",

issn = "0936-5214",

number = "3",

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TY - JOUR

T1 - Synthesis of amaryllidaceae constituents - An update

AU - Rinner, U.

AU - Hudlicky, T.

N1 - Export Date: 13 June 2023; Cited By: 119; Correspondence Address: T. Hudlicky; Department of Chemistry, Brock University, St. Catharines, Ont. L2S 3A1, 500 Glenridge Avenue, Canada; email: [email protected]; CODEN: SYNLE

PY - 2005/2/16

Y1 - 2005/2/16

N2 - Recent progress in the synthesis of major constituents of the Amaryllidaceae family is reviewed. Total syntheses of pancratistatin, narciclasine, and their 7-deoxy- derivatives, 7-deoxypancratistatin and lycoricidine, respectively, are covered in detail. Also included are preparations of truncated derivatives and unnatural mimics of pancratistatin. The literature coverage begins with the publication of the last major review in 1996 and is complete through the fall of 2004. © Georg Thieme Verlag Stuttgart.

AB - Recent progress in the synthesis of major constituents of the Amaryllidaceae family is reviewed. Total syntheses of pancratistatin, narciclasine, and their 7-deoxy- derivatives, 7-deoxypancratistatin and lycoricidine, respectively, are covered in detail. Also included are preparations of truncated derivatives and unnatural mimics of pancratistatin. The literature coverage begins with the publication of the last major review in 1996 and is complete through the fall of 2004. © Georg Thieme Verlag Stuttgart.

KW - Amaryllidaceae constituents (alkaloids)

KW - Total synthesis

KW - Unnatural and truncated derivatives

KW - 7 deoxypancratistatin

KW - antineoplastic agent

KW - lycoricidine

KW - narciclasine

KW - natural product

KW - pancratistatin

KW - phenanthridone

KW - toluenesulfonamide derivative

KW - unclassified drug

KW - acetylation

KW - amaryllidaceae

KW - animal cell

KW - antineoplastic activity

KW - cyclization

KW - cycloaddition

KW - deprotection reaction

KW - Diels Alder reaction

KW - drug screening

KW - drug synthesis

KW - epimerization

KW - esterification

KW - human

KW - human cell

KW - metallation

KW - Mitsunobu reaction

KW - mouse

KW - nonhuman

KW - oxidation

KW - plant

KW - reaction analysis

KW - review

KW - ring closing metathesis

KW - saponification

KW - structure activity relation

KW - Suzuki reaction

U2 - 10.1055/s-2005-862382

DO - 10.1055/s-2005-862382

M3 - Article

SN - 0936-5214

SP - 365

EP - 387

JO - Synlett

JF - Synlett

IS - 3

ER -

Synthesis of amaryllidaceae constituents - An update

Abstract

Forschungsfelder

IMC Forschungsschwerpunkte

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

UN SDGs

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