@article{a2ad838d8be14df287469c60b6aa2bd1,
title = "The transcription factor ZEB1 (δEF1) represses Plakophilin 3 during human cancer progression",
abstract = "Plakophilin 3 (PKP3) belongs to the p120ctn family of armadillo-related proteins predominantly functioning in desmosome formation. Here we report that PKP3 is transcriptionally repressed by the E-cadherin repressor ZEB1 in metastatic cancer cells. ZEB1 physically associates with two conserved E-box elements in the PKP3 promoter and partially represses the activity of corresponding human and mouse PKP3 promoter fragments in reporter gene assays. In human tumours ZEB1 is upregulated in invasive cancer cells at the tumour-host interface, which is accompanied by downregulation of PKP3 expression levels. Hence, the transcriptional repression of PKP3 by ZEB1 contributes to ZEB1-mediated disintegration of intercellular adhesion and epithelial to mesenchymal transition. {\textcopyright} 2007 Federation of European Biochemical Societies.",
keywords = "plakophilin, plakophilin 3, transcription factor, transcription factor zeb1, unclassified drug, uvomorulin, animal cell, article, cancer cell, cancer growth, cancer invasion, carcinogenesis, cell adhesion, cell transformation, controlled study, down regulation, epithelium cell, functional proteomics, genetic transcription, human, human cell, mesenchyme, metastasis, mouse, nonhuman, priority journal, promoter region, protein expression, protein function, reporter gene, transcription regulation, upregulation, Animals, Base Sequence, Cadherins, Disease Progression, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, Humans, Mice, Neoplasm Invasiveness, Neoplasms, Plakophilins, Promoter Regions (Genetics), Repressor Proteins, Transcription Factors, Tumor Cells, Cultured, Armadillo",
author = "K. Aigner and L. Descovich and M. Mikula and A. Sultan and B. Dampier and S. Bonn{\'e} and {van Roy}, F. and W. Mikulits and M. Schreiber and T. Brabletz and W. Sommergruber and N. Schweifer and A. Wernitznig and H. Beug and R. Foisner and A. Eger",
note = "cited By 80",
year = "2007",
month = mar,
day = "21",
doi = "10.1016/j.febslet.2007.03.026",
language = "English",
volume = "581",
pages = "1617--1624",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "8",
}
