The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug

R. Lucas, H. Hundsberger, M. Pflüger, B. Fischer, D. Morel, C. Braun, A. Wendel, T. Chakraborty, W. Schütt, C. Wiesner, J. Hamacher

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung


In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent. © 2007 Bentham Science Publishers Ltd.
Seiten (von - bis)336-340
FachzeitschriftLetters in Drug Design and Discovery
PublikationsstatusVeröffentlicht - 1 Juli 2007


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