The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug

R. Lucas; H. Hundsberger; M. Pflüger; B. Fischer; D. Morel; C. Braun; A. Wendel; T. Chakraborty; W. Schütt; C. Wiesner; J. Hamacher

doi:10.2174/157018007780867816

The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug

R. Lucas, H. Hundsberger, M. Pflüger, B. Fischer, D. Morel, C. Braun, A. Wendel, T. Chakraborty, W. Schütt, C. Wiesner, J. Hamacher

Institut Biotechnologie

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

Abstract

In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent. © 2007 Bentham Science Publishers Ltd.

Originalsprache	Englisch
Seiten (von - bis)	336-340
Seitenumfang	5
Fachzeitschrift	Letters in Drug Design and Discovery
Jahrgang	4
Ausgabenummer	5
DOIs	https://doi.org/10.2174/157018007780867816
Publikationsstatus	Veröffentlicht - 1 Juli 2007

IMC Forschungsschwerpunkte

Medical biotechnology

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

304005 Medizinische Biotechnologie

UN SDGs

Dieser Output leistet einen Beitrag zu folgendem(n) Ziel(en) für nachhaltige Entwicklung

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10.2174/157018007780867816

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abstract = "In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent. {\textcopyright} 2007 Bentham Science Publishers Ltd.",

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AU - Lucas, R.

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AU - Morel, D.

AU - Braun, C.

AU - Wendel, A.

AU - Chakraborty, T.

AU - Schütt, W.

AU - Wiesner, C.

AU - Hamacher, J.

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AB - In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent. © 2007 Bentham Science Publishers Ltd.

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KW - edema

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KW - hypersensitivity

KW - hyperuricemia

KW - hypokalemia

KW - hypomagnesemia

KW - hypotension

KW - immunomodulation

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KW - lung alveolus cell type 2

KW - lung alveolus epithelium

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KW - lung edema

KW - metabolic alkalosis

KW - peptide analysis

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The tumor necrosis factor-derived TIP peptide: A potential anti-edema drug

Abstract

IMC Forschungsschwerpunkte

ÖFOS 2012 - Österreichischen Systematik der Wissenschaftszweige

UN SDGs

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