Extracellular Vesicle in Inflammation

Extracellular Vesicles in Inflammation Inflammatory diseases are a major cause of morbidity, disability and mortality. More than 50% of all deaths are due to inflammatory diseases. In addition, there is evidence that chronic inflammation plays a role in aging. Inflammation is a double-edged sword: in a physiological context, it is important for defense against pathogens and clearance of cellular debris. However, prolonged or dysregulated inflammation can contribute to tissue damage and various diseases. Extracellular vesicles (EVs) regulate inflammation. Their properties depend on the cell type and the environment, so they can have both pro- and anti-inflammatory effects. The PhD program "EVs in Inflammation" provides scientific training with the aim of investigating the mechanisms of Extracellular Vesicles (EVs) in Inflammation. The program is run by the University of Continuing Education Krems (UWK), the IMC University of Applied Sciences Krems (IMC) and the Medical University of Vienna (MUW). It is supported by a network of renowned international collaborators to ensure international mobility of PhD students and a strong translational perspective. At the IMC, the immunoregulatory function of EVs secreted by MSCs or macrophages will be investigated after the activation of different Toll-like receptors.