Design and synthesis of benzothiazole schiff bases of potential antitumor activity

T. Al-Harthy; R. Abdel-Jalil; W.M. Zoghaib; M. Pflüger; E. Hofmann; H. Hundsberger

doi:10.3987/COM-16-13471

Design and synthesis of benzothiazole schiff bases of potential antitumor activity

T. Al-Harthy, R. Abdel-Jalil, W.M. Zoghaib, M. Pflüger, E. Hofmann, H. Hundsberger

Institute Biotechnology

Sultan Qaboos University

Research output: Contribution to journal › Article › peer-review

Abstract

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

Original language	English
Pages (from-to)	1282-1292
Number of pages	11
Journal	Heterocycles
Volume	92
Issue number	7
DOIs	https://doi.org/10.3987/COM-16-13471
Publication status	Published - 25 May 2016

IMC Research Focuses

Medical biotechnology

ÖFOS 2012 - Austrian Fields of Study

304005 Medical biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3987/COM-16-13471

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title = "Design and synthesis of benzothiazole schiff bases of potential antitumor activity",

abstract = "In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.",

author = "T. Al-Harthy and R. Abdel-Jalil and W.M. Zoghaib and M. Pfl{\"u}ger and E. Hofmann and H. Hundsberger",

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T1 - Design and synthesis of benzothiazole schiff bases of potential antitumor activity

AU - Al-Harthy, T.

AU - Abdel-Jalil, R.

AU - Zoghaib, W.M.

AU - Pflüger, M.

AU - Hofmann, E.

AU - Hundsberger, H.

PY - 2016/5/25

Y1 - 2016/5/25

N2 - In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

AB - In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

UR - https://www.scopus.com/pages/publications/84978712142

U2 - 10.3987/COM-16-13471

DO - 10.3987/COM-16-13471

M3 - Article

SN - 0385-5414

VL - 92

SP - 1282

EP - 1292

JO - Heterocycles

JF - Heterocycles

IS - 7

ER -

Design and synthesis of benzothiazole schiff bases of potential antitumor activity

Abstract

IMC Research Focuses

ÖFOS 2012 - Austrian Fields of Study

UN SDGs

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