Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

C. Wiesner; J. Kopecky; M. Pflueger; H. Hundsberger; B. Entler; C. Kleber; J. Atzler; P. Hrouzek; D. Stys; A. Lukesova; W. Schuett; R. Lucas

doi:10.2174/187231207783221385

Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

C. Wiesner, J. Kopecky, M. Pflueger, H. Hundsberger, B. Entler, C. Kleber, J. Atzler, P. Hrouzek, D. Stys, A. Lukesova, W. Schuett, R. Lucas

Institute Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

Original language	English
Pages (from-to)	254-260
Number of pages	7
Journal	Drug Metabolism Letters
Volume	1
Issue number	4
DOIs	https://doi.org/10.2174/187231207783221385
Publication status	Published - Dec 2007

Keywords

antiinflammatory agent
intercellular adhesion molecule 1
acute lung injury
article
biological model
cell line
chemistry
drug effect
endothelium cell
gene expression regulation
human
isolation and purification
lung alveolus
metabolism
neutrophil chemotaxis
Nostoc
pathophysiology
wound healing
Acute Lung Injury
Anti-Inflammatory Agents
Cell Line
Endothelial Cells
Gene Expression Regulation
Humans
Intercellular Adhesion Molecule-1
Models
Biological
Neutrophil Infiltration
Pulmonary Alveoli
Wound Healing

IMC Research Focuses

Medical biotechnology

ÖFOS 2012 - Austrian Fields of Study

304005 Medical biotechnology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/187231207783221385

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Wiesner, C., Kopecky, J., Pflueger, M., Hundsberger, H., Entler, B., Kleber, C., Atzler, J., Hrouzek, P., Stys, D., Lukesova, A., Schuett, W., & Lucas, R. (2007). Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites. Drug Metabolism Letters, 1(4), 254-260. https://doi.org/10.2174/187231207783221385

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title = "Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.",

abstract = "Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.",

keywords = "antiinflammatory agent, intercellular adhesion molecule 1, acute lung injury, article, biological model, cell line, chemistry, drug effect, endothelium cell, gene expression regulation, human, isolation and purification, lung alveolus, metabolism, neutrophil chemotaxis, Nostoc, pathophysiology, wound healing, Acute Lung Injury, Anti-Inflammatory Agents, Cell Line, Endothelial Cells, Gene Expression Regulation, Humans, Intercellular Adhesion Molecule-1, Models, Biological, Neutrophil Infiltration, Pulmonary Alveoli, Wound Healing",

author = "C. Wiesner and J. Kopecky and M. Pflueger and H. Hundsberger and B. Entler and C. Kleber and J. Atzler and P. Hrouzek and D. Stys and A. Lukesova and W. Schuett and R. Lucas",

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year = "2007",

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doi = "10.2174/187231207783221385",

language = "English",

volume = "1",

pages = "254--260",

journal = "Drug Metabolism Letters",

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Wiesner, C, Kopecky, J, Pflueger, M , Hundsberger, H , Entler, B, Kleber, C, Atzler, J, Hrouzek, P, Stys, D, Lukesova, A, Schuett, W & Lucas, R 2007, 'Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.', Drug Metabolism Letters, vol. 1, no. 4, pp. 254-260. https://doi.org/10.2174/187231207783221385

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T1 - Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

AU - Wiesner, C.

AU - Kopecky, J.

AU - Pflueger, M.

AU - Hundsberger, H.

AU - Entler, B.

AU - Kleber, C.

AU - Atzler, J.

AU - Hrouzek, P.

AU - Stys, D.

AU - Lukesova, A.

AU - Schuett, W.

AU - Lucas, R.

N1 - cited By 4

PY - 2007/12

Y1 - 2007/12

N2 - Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

AB - Acute lung injury is accompanied by an increased endothelial chemokine production and adhesion molecule expression, which may result in an extensive neutrophil infiltration. Moreover, a destruction of the alveolar epithelium and capillary endothelium may result in permeability edema. As such, the search for novel anti-inflammatory substances, able to downregulate these parameters as well as the tissue damage holds therapeutic promise. We therefore describe here the use of human endothelial cell-based in vitro assays for the detection of anti-inflammatory and wound-healing metabolites from cyanobacteria.

KW - antiinflammatory agent

KW - intercellular adhesion molecule 1

KW - acute lung injury

KW - article

KW - biological model

KW - cell line

KW - chemistry

KW - drug effect

KW - endothelium cell

KW - gene expression regulation

KW - human

KW - isolation and purification

KW - lung alveolus

KW - metabolism

KW - neutrophil chemotaxis

KW - Nostoc

KW - pathophysiology

KW - wound healing

KW - Acute Lung Injury

KW - Anti-Inflammatory Agents

KW - Cell Line

KW - Endothelial Cells

KW - Gene Expression Regulation

KW - Humans

KW - Intercellular Adhesion Molecule-1

KW - Models

KW - Biological

KW - Neutrophil Infiltration

KW - Pulmonary Alveoli

KW - Wound Healing

U2 - 10.2174/187231207783221385

DO - 10.2174/187231207783221385

M3 - Article

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VL - 1

SP - 254

EP - 260

JO - Drug Metabolism Letters

JF - Drug Metabolism Letters

IS - 4

ER -

Endothelial cell-based methods for the detection of cyanobacterial anti-inflammatory and wound-healing promoting metabolites.

Abstract

Keywords

IMC Research Focuses

ÖFOS 2012 - Austrian Fields of Study

UN SDGs

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