Phosphoramide Hydrogels as Biodegradable Matrices for Inkjet Printing and Their Nano-Hydroxyapatite Composites

Mahsa Mostofizadeh, Michael Kainz, Farzaneh Alihosseini, Stephan Haudum, Mostafa Youssefi, Peter Bauer, Iurii Gnatiuk, Oliver Brüggemann, Katja Zembsch, Uwe Rinner, Catarina Coelho, Elena Guillén, Ian Teasdale

Research output: Contribution to journalArticlepeer-review

Abstract

Inkjet printing is a leading technology in the biofabrication of three-dimensional biomaterials, offering digital, noncontact deposition with micron-level precision. Among these materials, hydroxyapatite is widely recognized for its use in bone tissue engineering. However, most hydroxyapatite-laden inks are unsuitable for inkjet printing. To address this, we developed photocurable and biodegradable phosphoramide-based hydrogels containing thiol-functionalized polyethylene glycol via click chemistry. These hydrogels degrade into phosphates, the natural component of bone. The rheological properties of the inks are finely tuned through chemical design to meet the requirements of nanohydroxyapatite composite inks for piezoelectric inkjet printing. We demonstrated their printability using simple geometric patterns, showcasing a versatile and efficient solution for the precise inkjet printing of biomaterial composites.

Original languageEnglish
Pages (from-to)52902-52910
Number of pages9
JournalACS Applied Materials and Interfaces
Volume16
Issue number39
DOIs
Publication statusPublished - 2 Oct 2024

Keywords

  • additive manufacturing
  • inkjet printing
  • nano-hydroxyapatite
  • phosphoramide
  • tissue engineering

IMC Research Focuses

  • Materials science

ÖFOS 2012 - Austrian Fields of Study

  • 104018 Polymer chemistry

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