Abstract
In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent. © 2007 Bentham Science Publishers Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 336-340 |
| Number of pages | 5 |
| Journal | Letters in Drug Design and Discovery |
| Volume | 4 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Jul 2007 |
Keywords
- beta adrenergic receptor stimulating agent
- cytokine
- dipeptidyl carboxypeptidase inhibitor
- diuretic agent
- lectin
- tumor necrosis factor
- angioneurotic edema
- carbohydrate intolerance
- drug potency
- edema
- heart arrhythmia
- human
- hypersensitivity
- hyperuricemia
- hypokalemia
- hypomagnesemia
- hypotension
- immunomodulation
- kidney perfusion
- lung alveolus cell type 2
- lung alveolus epithelium
- lung clearance
- lung edema
- metabolic alkalosis
- peptide analysis
- priority journal
- review
- side effect
IMC Research Focuses
- Medical biotechnology
ÖFOS 2012 - Austrian Fields of Study
- 304005 Medical biotechnology
